Diabetes Mellitus and the Kidneys

Gal, Arnon;Burchell, Richard K.

Abstract

Diabetic kidney disease (DKD) is a chronic progressive kidney disease that is the most common cause of end-stage renal failure in people in the western world.1 DKD results from multifactorial pathophysiological mechanisms and clinically manifests with proteinuria, subsequent progressive decline in glomerular filtration rate (GFR), and ultimately progression to end-stage renal disease.2 There is minimal published information about DKD in companion animals in the veterinary literature. The first part of this review will focus on the pathophysiology of DKD, derived mainly from the human medical literature and rodent models of DKD. Wherever there was corresponding information relevant to companion animals, we mentioned it. The second part of this review focuses on the limited veterinary literature that loosely supports the existence of DKD as a clinical entity in companion animals.

Journal

Veterinary Clinics of North America - Small Animal Practice

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1878-1306

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Elsevier

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DOI

10.1016/j.cvsm.2023.01.006