The application of long‑read sequencing in clinical settings

Journal Publication ResearchOnline@JCU
Oehler, Josphine B.;Wright, Helen;Stark, Zornitza;Mallett, Andrew;Schmitz, Ulf
Abstract

Long-read DNA sequencing technologies have been rapidly evolving in recent years, and their ability to assess large and complex regions of the genome makes them ideal for clinical applications in molecular diagnosis and therapy selection, thereby providing a valuable tool for precision medicine. In the third-generation sequencing duopoly, Oxford Nanopore Technologies and Pacific Biosciences work towards increasing the accuracy, throughput, and portability of long-read sequencing methods while trying to keep costs low. These trades have made long-read sequencing an attractive tool for use in research and clinical settings. This article provides an overview of current clinical applications and limitations of long-read sequencing and explores its potential for point-of-care testing and health care in remote settings.

Journal

Human Genomics

Publication Name

N/A

Volume

17

ISBN/ISSN

1479-7364

Edition

N/A

Issue

N/A

Pages Count

13

Location

N/A

Publisher

BioMed Central

Publisher Url

N/A

Publisher Location

N/A

Publish Date

N/A

Url

N/A

Date

N/A

EISSN

N/A

DOI

10.1186/s40246-023-00522-3