A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium
Journal Publication ResearchOnline@JCUWardhani, Kartika;Levina, Aviva;Sun, Biyun;Grau, Georges E.R.;Keene, F. Richard;Collins, J. Grant;Lay, Peter A.
Abstract
A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
Journal
Chemical Communications
Publication Name
Chemical Communications
Volume
59
ISBN/ISSN
1364-548X
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Pages Count
4
Location
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Publisher
Royal Society of Chemistry
Publisher Url
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Publisher Location
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Publish Date
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Date
N/A
EISSN
N/A
DOI
10.1039/d2cc05827h