A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Journal Publication ResearchOnline@JCU
Wardhani, Kartika;Levina, Aviva;Sun, Biyun;Grau, Georges E.R.;Keene, F. Richard;Collins, J. Grant;Lay, Peter A.
Richard Keene
Abstract

A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

Journal

Chemical Communications

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Volume

59

ISBN/ISSN

1364-548X

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Pages Count

4

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Publisher

Royal Society of Chemistry

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EISSN

N/A

DOI

10.1039/d2cc05827h