Cellular Cytotoxicity and Multiple Sclerosis

Other Publication ResearchOnline@JCU
Willson, Annie;Jordan, Margaret
Abstract

Multiple sclerosis (MS) is an autoimmune disease in which discrete central nervous system lesions result from perivascular immune cell infiltration associated with damage to myelin (demyelination), oligodendrocytes and neurons. This culminates in debilitating neurological symptoms, primarily affecting women in their child-bearing years. Both the innate and adaptive branches of the immune system have been implicated in disease initiation and progression, and although the underlying cause remains elusive, there is compelling evidence for a complex interaction between genetic and environmental factors, leading to inflammation and neurodegeneration. Both direct cellular toxicity and antibody-dependent cellular cytotoxicity (ADCC) involving several cell types have been identified in playing major roles. These cells and their interactions in the pathogenesis of MS will be discussed.

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Publication Name

Cytotoxicity

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ISBN/ISSN

978-1-80356-246-9

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Pages Count

22

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Publisher

IntechOpen

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Publisher Location

London, United Kingdom

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DOI

10.5772/intechopen.105681