RNA systems biology for cancer: From diagnosis to therapy

Other Publication ResearchOnline@JCU
Amirkhah, Raheleh;Farazmand, Ali;Wolkenhauer, Olaf;Schmitz, Ulf
Abstract

It is due to the advances in high-throughput omics data generation that RNA species have re-entered the focus of biomedical research. International collaborate efforts, like the ENCODE and GENCODE projects, have spawned thousands of previously unknown functional non-coding RNAs (ncRNAs) with various but primarily regulatory roles. Many of these are linked to the emergence and progression of human diseases. In particular, interdisciplinary studies integrating bioinformatics, systems biology, and biotechnological approaches have successfully characterized the role of ncRNAs in different human cancers. These efforts led to the identification of a new tool-kit for cancer diagnosis, monitoring, and treatment, which is now starting to enter and impact on clinical practice. This chapter is to elaborate on the state of the art in RNA systems biology, including a review and perspective on clinical applications toward an integrative RNA systems medicine approach. The focus is on the role of ncRNAs in cancer.

Journal

Methods in Molecular Biology

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Volume

1386

ISBN/ISSN

978-1-4939-3283-2

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Pages Count

26

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Publisher

Springer

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Publisher Location

New York, NY, USA

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N/A

DOI

10.1007/978-1-4939-3283-2_14