Resident memory t cells and their role within the liver
Journal Publication ResearchOnline@JCUAbstract
Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses—the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM ) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.
Journal
International Journal of Molecular Sciences
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Volume
21
ISBN/ISSN
1422-0067
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Issue
22
Pages Count
15
Location
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Publisher
MDPI
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EISSN
N/A
DOI
10.3390/ijms21228565