Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant-based polymers

Journal Publication ResearchOnline@JCU
Romo-Rico, Jesus;Krishna, Smriti Murali;Golledge, Jonathan;Hayles, Andrew;Vasilev, Krasimir;Jacob, Mohan V.
Jonathan GolledgeMohan Jacob
Abstract

Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP-OSMs) were fabricated by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP-OSMs were investigated. Polymers fabricated by RF-PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP-OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required.

Journal

Plasma Processes and Polymers

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Volume

19

ISBN/ISSN

1612-8869

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Issue

7

Pages Count

10

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Publisher

Wiley

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Date

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EISSN

N/A

DOI

10.1002/ppap.202100220