T cell differentiation and lineage choice are determined by the TCR
Journal Contribution ResearchOnline@JCUAbstract
Next-generation sequencing technologies have revealed that adaptive immunity is underpinned by a vast array of T cell receptors (TCRs). However, it has proven difficult to interpret these extensive datasets, in part because the field previously lacked a comprehensive and internally controlled reference atlas encompassing the full spectrum of phenotypically defined subsets in each lineage. To address this knowledge gap, we sequenced 74 million TCRs expressed by discrete CD4+ and CD8+ memory T cell populations across genetically unrelated individuals, providing a resource to inform basic and applied studies of repertoire compartmentalisation within the adaptive immune system. Using this resource, we found that T cell differentiation could not be explained solely by the self-renewing effector model and, unexpectedly, that T cell fate could be predicted by specific genetic and physicochemical features of the TCR.
Journal
FASEB Journal
Publication Name
N/A
Volume
36
ISBN/ISSN
1530-6860
Edition
N/A
Issue
S1
Pages Count
3
Location
N/A
Publisher
John Wiley & Sons, Inc.
Publisher Url
N/A
Publisher Location
N/A
Publish Date
N/A
Url
N/A
Date
N/A
EISSN
N/A
DOI
10.1096/fasebj.2022.36.S1.R6136