Nanomaterial-based label-free electrochemical aptasensors for the detection of thrombin
Journal Publication ResearchOnline@JCUAbstract
Thrombin plays a central role in hemostasis and its imbalances in coagulation can lead to various pathologies. It is of clinical significance to develop a fast and accurate method for the quantitative detection of thrombin. Electrochemical aptasensors have the capability of combining the specific selectivity from aptamers with the extraordinary sensitivity from electrochemical techniques and thus have attracted considerable attention for the trace-level detection of thrombin. Nanomaterials and nanostructures can further enhance the performance of thrombin aptasensors to achieve high sensitivity, selectivity, and antifouling functions. In highlighting these material merits and their impacts on sensor performance, this paper reviews the most recent advances in label-free electrochemical aptasensors for thrombin detection, with an emphasis on nanomaterials and nanostructures utilized in sensor design and fabrication. The performance, advantages, and limitations of those aptasensors are summarized and compared according to their material structures and compositions.
Journal
Biosensors
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N/A
Volume
12
ISBN/ISSN
2079-6374
Edition
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Issue
4
Pages Count
27
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Publisher
MDPI
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EISSN
N/A
DOI
10.3390/bios12040253