Massively parallel sequencing in hereditary prostate cancer families reveals a rare risk variant in the DNA repair gene, RAD51C

Journal Contribution ResearchOnline@JCU
Marthick, James R.;Raspin, Kelsie;Foley, Georgea R.;Blackburn, Nicholas B.;Banks, Annette;Donovan, Shaun;Malley, Roslyn C.;Field, Matthew A.;Stanford, Janet L.;Ostrander, Elaine A.;FitzGerald, Liesel M.;Dickinson, Joanne L.
Matt Field
Abstract

[Extract] Dear Editor, Global statistics show that prostate cancer (PrCa) is the second most common non-cutaneous cancer diagnosed in men, and currently, it is the most commonly diagnosed cancer in Australian men [1]. While PrCa is a clinically complex, heterogeneous disease, it is one of the most heritable common cancers, with family history a strong predictor of susceptibility [2]. However, the identification of rare, high-risk germline variants for PrCa has lagged significantly behind other heritable cancers [3].

Journal

European Journal of Cancer

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Volume

159

ISBN/ISSN

1879-0852

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Pages Count

4

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Publisher

Elsevier

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EISSN

N/A

DOI

10.1016/j.ejca.2021.09.038