Interactions of osteoprogenitor cells with a novel zirconia implant surface
Conference Contribution ResearchOnline@JCUAbstract
Objectives: This study evaluated the in-vitro response of a mouse pre-osteoblast cellline on a novel, sandblasted zirconia surface compared to titanium. Methods: The novel zirconia surface was created by sandblasting at 6cm with 150-200μm alumina particles under 0.6MPa pressure, for 3 minutes. MC3T3-E1 subclone 4osteoblast precursor cell line was cultured on either sandblasted titanium (SBCpTi) orsandblasted zirconia (SBY-TZP). The surface topography was analysed by three-dimensional laser microscopy measurements and scanning electron microscope. The chemical state of each surface was also assessed using wettability measurements. The cellular response was quantied by morphology (day 1), proliferation (day 1, 3, 5, 7, 9),viability (day 1, 9) and migration (0, 6, 24 hours). Results: The sandblasting surface treatment was successful for both titanium andzirconia, increasing surface roughness and obtaining a defi ned surface topography ,however, titanium was able to achieve a more apparent nano-topography. Thewettability of the two surfaces showed no significant difference. The zirconia surface resulted in improved cellular spreading and a significantly increased rate of migration compared to titanium. However, cellular proliferation and viability of the cell line was not significantly different on the two surfaces. Conclusions: The novel, roughened zirconia surface elicited cell stimulating propertiescomparable or exceeding that of titanium. Therefore, this novel zirconia surface can bean acceptable substitute for titanium as a dental implant material. Further in vitro andin vivo animal studies would be important to further assess zirconia and this novelsurface as suitable for dental implants and an alternative to titanium-based dentalimplants; prior to clinical studies.
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98th General Session & Exhibition of the IADR/49th Annual Meeting & Exhibition of the AADR
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1
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Washington, D.C., USA
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International Association for Dental Research
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Washington, DC, USA
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