Sugar alters the level of serum insulin and plasma glucose and the serum cortisol: DHEAS ratio in female migraine sufferers
Journal Publication ResearchOnline@JCUAbstract
Early work has highlighted that a large percentage of migraineurs may have an altered glucidic methabolis due to carbohydrate-induced hyperinsulinism. The aim of this study was to assess the effect of sucrose on biomarkers of energy metabolism and utilization in migraineous females. A total of 16 participants (8 = Migraine, 8 = Non-migraine) at the mid-point of their menstrual cycle underwent a 15 hour fast prior to ingesting 75g sucrose dissolved in 175g water. Blood sampling for the assessment of serum insulin, serum cortisol and serum dehydroepiandrosterone sulfate (DHEAS) and plasma glucose was conducted upon arrival at 0900 h and then at regular 15-min intervals across a 150-min experimental period. The results showed a significant alteration in serum insulin and plasma glucose following sucrose ingestion in the migraine and non-migraine groups. In addition, significant group differences were observed in the level of serum insulin, serum DHEAS, and the cortisol:DHEAS ratio with migraine participants on average recording a higher sucrose-induced serum insulin level and lower DHEAS level and cortisol:DHEAS ratio when group data was compared. It was concluded that while sucrose consumption may potentiate serum insulin in migraineurs this does not result in the development of sucrose-induced hypoglycemia in migraine or non-migraine participants.
Journal
Appetite
Publication Name
N/A
Volume
55
ISBN/ISSN
1095-8304
Edition
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Issue
3
Pages Count
7
Location
N/A
Publisher
Elsevier
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Publisher Location
N/A
Publish Date
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Url
N/A
Date
N/A
EISSN
N/A
DOI
10.1016/j.appet.2010.09.007