Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones

Journal Publication ResearchOnline@JCU
Mumtaz, Saira;Robertson, Mark J.;Oelgemöller, Michael
Michael Oelgemoeller
Abstract

An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical–thermal–thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.

Journal

Molecules

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N/A

Volume

24

ISBN/ISSN

1420-3049

Edition

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Issue

24

Pages Count

10

Location

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Publisher

MDPI

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Date

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EISSN

N/A

DOI

10.3390/molecules24244527