Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice

Journal Publication ResearchOnline@JCU
Kraeuter, Ann-Katrin;Archambault, Nadia;van den Buuse, Maarten;Sarnyai, Zoltan
Zoltan Sarnyai
Abstract

We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.

Journal

Schizophrenia Research

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Volume

212

ISBN/ISSN

1573-2509

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Pages Count

4

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Publisher

Elsevier

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EISSN

N/A

DOI

10.1016/j.schres.2019.08.002