Development, ontogeny, and maintenance of TCRab+ CD8aa IEL

Journal Publication ResearchOnline@JCU
Ruscher, Roland;Hogquist, Kristin A.
Roland Ruscher
Abstract

The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells—intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRab+ subset of CD8aa IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8aa IEL, and highlight yet unanswered questions for future studies.

Journal

Current Opinion in Immunology

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Volume

58

ISBN/ISSN

1879-0372

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Pages Count

6

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Publisher

Elsevier

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Date

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EISSN

N/A

DOI

10.1016/j.coi.2019.04.010