Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products
Other Publication ResearchOnline@JCUAbstract
Natural resources including plants, animals and microorganisms contain enormous chemical diversity with huge potential for therapeutic applications. Identifying new drug lead compounds from these sources, which is the first critical stage of the drug development process, is a demanding task requiring multi-disciplinary approaches including material identification, collection, extraction, isolation, purification, characterisation, structure elucidation, identification, biological activity screening, lead optimisation, and pre-clinical evaluation in animal models. To support all these stages of drug lead identification, life science manufacturers have developed large numbers of powerful tools and technologies that have led to new paradigms in high-throughput drug discovery. Our chapter will focus on this first critical stage of drug discovery – identification of drug lead compounds from natural sources. We present the techniques and technologies currently available to screen bioactive natural products within the so-called “metabolomics” field.
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Natural Products and Drug Discovery: An Integrated Approach
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ISBN/ISSN
978-0-08-102081-4
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Pages Count
31
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Elsevier
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Publisher Location
Amsterdam, Netherlands
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DOI
10.1016/B978-0-08-102081-4.00016-2