Myostatin: expanding horizons
Journal Publication ResearchOnline@JCUAbstract
Myostatin is a secreted growth and differentiation factor that belongs to the TGF-b superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.
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Volume
67
ISBN/ISSN
1521-6543
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Issue
8
Pages Count
12
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Publisher
Wiley-Blackwell
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Date
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EISSN
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DOI
10.1002/iub.1392