Longevity Klotho gene polymorphism and the risk of dementia in older men
Journal Publication ResearchOnline@JCUAbstract
Introduction: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk. Methods: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures. Results: The annual rate of dementia was 17.2%o (95%CI = 14.0-21.1; total = 5053 person-years), and 14.0%o (95%CI = 10.6-18.4; 3582 person-years), 23.5%o (95%CI = 16.6-33.2; 1363 person-years) and 46.4%o (95%CI = 19.3-111.5; 108 person-years) for men with the TT, TG and GG genotypes. Compared with the TT genotype, the sub-hazard ratios of dementia associated with the TG and GG genotypes were 1.6 (95%CI = 1.0, 2.5; p = 0.030) and 3.5 (95%CI = 1.3, 9.1; p = 0.011). Discussion: The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis).
Journal
Maturitas
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Volume
101
ISBN/ISSN
0378-5122
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Pages Count
5
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Publisher
Elsevier
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DOI
10.1016/j.maturitas.2017.04.005