Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013

Journal Publication ResearchOnline@JCU
Rith, Sareth;Davis, C. Todd;Duong, Veasna;Sar, Borann;Horm, Srey Viseth;Chin, Savuth;Ly, Sovann;Laurent, Denis;Richner, Beat;Oboho, Ikwo;Jang, Yunho;Davis, William;Thor, Sharmi;Balish, Amanda;Iuliano, A. Danielle;Sorn, San;Holl, Davun;Sok, Touch;Seng, Heng Seng;Tarantola, Arnaud;Tsuyuoka, Reiko;Parry, Amy;Chea, Nora;Allal, Lotfi;Kitsutani, Paul;Warren, Dora;Prouty, Michael;Horwood, Paul;Widdowson, Marc-Alain;Lindstrom, Stephen;Villanueva, Julie;Donis, Ruben;Cox, Nancy;Buchy, Phillipe
Paul Horwood
Abstract

Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.

Journal

Journal of Virology

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Volume

88

ISBN/ISSN

1098-5514

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Issue

23

Pages Count

13

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Publisher

American Society for Microbiology

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EISSN

N/A

DOI

10.1128/JVI.01887-14