Risk of dementia and death in community-dwelling older men with bipolar disorder
Journal Publication ResearchOnline@JCUAbstract
Background: Bipolar disorder has been associated with cognitive decline, but confirmatory evidence from a community-derived sample of older people is lacking. Aims: To investigate the 13-year risk of dementia and death in older adults with bipolar disorder. Method: Cohort study of 37 768 men aged 65-85 years. Dementia (primary) and death (secondary), as recorded by electronic record linkage, were the outcomes of interest. Results: Bipolar disorder was associated with increased adjusted hazard ratio (HR) of dementia (HR=2.30, 95% CI 1.80-2.94). The risk of dementia was greatest among those with <5 years of history of bipolar disorder or who had had illness onset after 70 Steers of age. Bipolar disorder was also associated with increased mortality (HR=1.51, 95% CI 1.28-1.77). Competing risk regression showed that bipolar disorder was associated with increased hazard of death by suicide, accidents, pneumonia or influenza, and diseases of the liver and digestive system. Conclusions: Bipolar disorder in later life is associated with increased risk of dementia and premature death.
Journal
The British Journal of Psychiatry
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Volume
209
ISBN/ISSN
1472-1465
Edition
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Issue
2
Pages Count
6
Location
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Publisher
Royal College of Psychiatrists
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Publisher Location
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Publish Date
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Date
N/A
EISSN
N/A
DOI
10.1192/bjp.bp.115.180059