Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Journal Publication ResearchOnline@JCU
Emeto, Theophilus I.;Moxon, Joseph V.;Au, Minnie;Golledge, Jonathan
Iyke EmetoJonathan Golledge
Abstract

Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.

Journal

Clinical Science

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Volume

130

ISBN/ISSN

1470-8736

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Issue

5

Pages Count

15

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Publisher

Portland Press

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Publisher Location

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Date

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EISSN

N/A

DOI

10.1042/CS20150547