Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development
Journal Publication ResearchOnline@JCUAbstract
Hepatocellular carcinoma (HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis (NASH). NASH is a complex metabolic disorder that can impact greatly on hepatic function. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give an overview of the recent novel mechanisms published that have been associated with NASH and subsequent HCC progression. We will focus our discussion on inflammation and gut derived inflammation and how they contribute to NASH driven HCC.
Journal
World Journal of Gastroenterology
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N/A
Volume
20
ISBN/ISSN
2219-2840
Edition
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Issue
44
Pages Count
10
Location
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Publisher
Baishideng Publishing Group
Publisher Url
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Publisher Location
N/A
Publish Date
N/A
Url
N/A
Date
N/A
EISSN
N/A
DOI
10.3748/wjg.v20.i44.16464