Role of adiponectin and its receptors in cancer

Obeid, Stephanie;Hebbard, Lionel

Abstract

Adiponectin (APN), a novel hormone/cytokine derived from adipocyte tissue, is involved in various physiological functions. Genetics, nutrition, and adiposity are factors contributing to circulating plasma concentrations of APN. Clinical correlation studies have shown that lower levels of serum APN are associated with increased malignancy of various cancers, such as breast and colon cancers, suggesting that APN has a role in tumorigenesis. APN affects insulin resistance, thus further influencing cancer development. Tumor cells may express receptors for APN. Cellular signaling is the mechanism by which APN exerts its host-protective responses. These factors suggest that serum APN levels and downstream signaling targets of APN may serve as potential diagnostic markers for malignancies. Further research is necessary to clarify the exact role of APN in cancer diagnosis and therapy.

Journal

N/A

Publication Name

N/A

Volume

ISBN/ISSN

2095-3941

Edition

N/A

Issue

Pages Count

Location

N/A

Publisher

Tianjin Yike Daxue Fushu Zhongliu Yiyuan

Publisher Url

N/A

Publisher Location

N/A

Publish Date

N/A

Url

N/A

Date

N/A

EISSN

N/A

DOI

10.7497/j.issn.2095-3941.2012.04.001