Low-dose aspirin and ibuprofen's sterilizing effects on mycobacterium tuberculosis suggest safe new adjuvant therapies for tuberculosis

Eisen, Damon P.;McBryde, Emma S.;Walduck, Anna

Abstract

[Extract] To the editor — The report on the intrinsic antimycobacterial activity of ibuprofen and low-dose aspirin in a novel murine tuberculosis model is fascinating and of relevance in the field. The paired advances of reporting new drug targets and further describing a readily reproducible model using commercially available C3HeB/FeJ mice is exciting. The authors have chosen not to describe further work on mechanisms of the nonsteroidal antiinflammatory drug (NSAID) effects in their preliminary report, but the accompanying editorial considers the antiinflammatory role of these cyclooxygenase inhibitors, revolving around prostaglandin (particularly PGE2) inhibition and consequent immune mediator cellular effects.

Journal

Journal of Infectious Diseases

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208

ISBN/ISSN

1537-6613

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Publisher

University of Chicago Press

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DOI

10.1093/infdis/jit476