Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

Journal Publication ResearchOnline@JCU
Williams, Natasha L.;Morris, Jodie L.;Rush, Catherine M.;Ketheesan, Natkunam
Catherine Rush
Abstract

Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.

Journal

Microbes and Infection

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Volume

17

ISBN/ISSN

1769-714X

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Issue

4

Pages Count

6

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Publisher

Elsevier

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Publisher Location

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Date

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EISSN

N/A

DOI

10.1016/j.micinf.2014.12.007