Exercise is medicine: case report of a woman with smoldering multiple myeloma
Journal Publication ResearchOnline@JCUAbstract
Purpose: This study aimed to evaluate the influence of a supervised training program on the changes in serum monoclonal protein level (i.e., IgG), percentage of bone marrow plasma cells (BMPCs), fitness performance, and cardiac autonomic control (i.e., HR variability [HRV] and HR complexity [HRC]) in a female diagnosed with smoldering multiple myeloma (SMM). Methods: A middle-age female patient with smoldering multiple myeloma and former elite athlete was monitored for 4 yr while participating in a supervised multimodal training regimen designed for the development of various physical capacities. The patient had the possibility of self-selection of daily training volume. Changes in fitness components, IgG levels, and BMPCs were evaluated throughout a 4-yr monitoring period (i.e., follow-up). HRV was examined via 24-h HR recordings during a 6-wk period at the second and the third year of the follow-up. Results: Exercise performance in all fitness components was improved while IgG levels and BMPCs decreased (from 2.53 to 1.84 g·dL⁻¹ and from 20% to 10%, respectively). Time and frequency domain HRV parameters exhibited significant increases (18%–29%) with HRC remaining unchanged. Conclusions: The current case report results indicated that a multimodal training program designed for the development of various physical capacities improved exercise performance, hematological function, and cardiac autonomic control that may improve long-term prognosis for SMM. Examination of similar exercise training regimens for hematological and other cancer populations may assist in the development of simple nonpharmacological treatments for improved prognosis.
Journal
Medicine and Science in Sports and Exercise
Publication Name
N/A
Volume
45
ISBN/ISSN
1530-0315
Edition
N/A
Issue
7
Pages Count
6
Location
N/A
Publisher
Lippincott, Williams & Wilkins
Publisher Url
N/A
Publisher Location
N/A
Publish Date
N/A
Url
N/A
Date
N/A
EISSN
N/A
DOI
10.1249/MSS.0b013e3182880359