Synthesis and crystal structure of lithium alendronate

Journal Publication ResearchOnline@JCU
Deacon, Glen B.;Greenhill, Neil B.;Junk, Peter C.;Wiecko, Michal
Peter Junk
Abstract

A new monovalent metal alendronate [Li(H4L)(H2O)2] [H5L = H2N(CH2)3C(OH)(PO3H2)2] (1) has been synthesized from lithium carbonate and alendronic acid and characterized by single-crystal X-ray diffraction as well as infrared spectroscopy, nuclear magnetic resonance, and electrospray mass spectrometry. Compound 1 is monomeric, and the four coordinate Li ion is coordinated by one oxygen of each phosphonate group and two waters in a distorted tetrahedral array. Extensive hydrogen bonding links each complex molecule to 10 others giving a 3-D supramolecular network.

Journal

Journal of Coordination Chemistry

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Volume

64

ISBN/ISSN

1029-0389

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Issue

1

Pages Count

7

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Publisher

Taylor & Francis

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Publisher Location

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Date

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EISSN

N/A

DOI

10.1080/00958972.2010.538389