Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate
Journal Publication ResearchOnline@JCUAndrews, Philip C.;Blair, Victoria L.;Ferrero, Richard L.;Junk, Peter C.;Kumar, Ish
Abstract
Reaction of Bi((OᵗBu)₃ with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O₂C(C₆H₄)OAc)₃]∞ 1 (O₂C(C₆H₄)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori >= 6.25 mu g mL⁻¹), while the inclusion of a stoichiometric equivalent of (KOᵗBu)leads to crystals of the bismuthate salt [KBi(O₂C(C₆H₄)OAc)₄]∞ 2.
Journal
Chemical Communications
Publication Name
N/A
Volume
49
ISBN/ISSN
1364-548X
Edition
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Issue
28
Pages Count
3
Location
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Publisher
Royal Society of Chemistry
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EISSN
N/A
DOI
10.1039/c3cc40645h