Synthesis and characterisation of bismuth(III) aminoarenesulfonate complexes and their powerful bactericidal activity against Helicobacter pylori
Journal Publication ResearchOnline@JCUAbstract
The synthesis and characterisation of nine new tris-substituted bismuth(III) aminoarenesulfonates of the general formula [Bi(O₃S-Rᴺ)₃] (Rᴺ=o-aminophenyl 1, m-aminophenyl 2, 6-amino-3-methoxyphenyl 3, p-aminophenyl 4, 2-pyridyl 5, o-aminonaphthyl 6, 5-aminonaphthyl 7, 4-amino-3-hydroxynaphthyl 8 and 5-isoquinolinyl 9) is described. Two synthetic strategies, using Ag₂O and [Bi(OtBu)₃], were explored and compared. The possibility to access heteroleptic bismuth(III) complexes with the new silver(I) metathesis reaction is demonstrated with the synthesis of the heteroleptic bismuth(III) aminoarenesulfonate complexes [PhBi(O₃S-P2)₂(dmso)] 10, [Ph₂Bi(O₃S-P2)]∞ 11 and [PhBi(O₃S-P2)₂]∞ 12, of which the solid state structures 10 and 12 are presented (2P-SO₃⁻=2-pyridinesulfonate). These complexes offer remarkable in-vitro activity against three standard laboratory strains of Helicobacter pylori (H. pylori) as demonstrated by their exceptionally low minimum inhibitory concentration (MIC) values of 0.049gmL⁻¹ for the strains 251 and B128, which places most MIC values in the nano-molar region. These results demonstrate the importance of the amino functionality in addition to the sulfonate group on the bactericidal properties against H. pylori.
Journal
N/A
Publication Name
N/A
Volume
19
ISBN/ISSN
1521-3765
Edition
N/A
Issue
17
Pages Count
12
Location
N/A
Publisher
Wiley-VCH
Publisher Url
N/A
Publisher Location
N/A
Publish Date
N/A
Url
N/A
Date
N/A
EISSN
N/A
DOI
10.1002/chem.201204220