Plasticity is the differentiated state of CD4 T cells

Journal Publication ResearchOnline@JCU
Baxter, Alan G.;Jordan, Margaret A.
Margaret Jordan
Abstract

[Extract]The recent application of targeted mutation technologies to lymphocyte fate mapping1 has facilitated the in vivo analysis of CD4 T cells subsequent to their differentiation. The fate mapping of IL17-producing cells has shown them to be responsive to environmental cues in fungal infection and central nervous system autoimmunity. Now Stockinger's group reports that many IL17-producing CD4⁺ T cells home to intestinal Peyer's patches (PP) and convert to a follicular helper T cell (TFH) phenotype, providing critical support for T-dependent IgA responses.

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10

ISBN/ISSN

2042-0226

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Issue

5

Pages Count

4

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Publisher

Chinese Society of Immunology

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DOI

10.1038/cmi.2013.29