Abstract
Stanton and Fletcher [1] described a 1913 outbreak of a septicaemic disease in a guinea pig colony at the Institute for Medical Research in Kuala Lumpur, Malaya. They isolated an infectious agent from diseased animais that was indistinguishable from Whitmore's bacillus (at that time na ned Bacillus whitmorii). They named the disease "melioidosis". Over the next decades, they and others in Southeast Asia documented numerous human cases and several cases in wild and domesticated animais. Early experimental infection studies by Stanton and Fletcher [2] demonstrated the relative susceptibility of rodents and goats, compared to other animais such as horses and monkeys. These initial investigations also showed that susceptible animais can be infected with the organism by ingestion, by contamination ofmucous membranes or abraded skin or by injection by any route. Stanton and Fletcher [2] also pioneered the serological tests used for diagnosing the disease over the subsequent decades.
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Publication Name
Melioidosis: a century of observation and research
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ISBN/ISSN
978-0-444-53479-8
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Pages Count
24
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Publisher
Elsevier
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The Netherlands
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