A sweeter way to combat Helicobacter pylori? Bismuth(III) complexes and oxido-clusters derived from non-nutritive sweeteners and their activity against H. pylori
Journal Publication ResearchOnline@JCUAbstract
Eight new homo-and hetero-leptic bismuth(III) complexes and two new polynuclear bismuth(III) oxido clusters derived from acetosulfame (AceH) and cyclamic acid (CycH₂) have been synthesised and characterised. Complexes, [Ph2Bi(Ace)] 1, [Bi(Ace)3] 2, [PhBi(Ace)2] 3, [Bi(CycH)₃] 6, [Ph₂Bi(CycH)] 7 and [PhBi(CycH)₂] 8 were synthesised by treating BiPh3 with the appropriate acid in 1:1, 1:2 and 1:3 stoichiometric ratios under solvent-free or solvent-mediated conditions. Complex 4, [Bi(OH)(Ace)₂], was obtained from the hydrolysis of 3. [Bi2(Cyc)3] 9 was obtained from the reaction of cyclamic acid with (Bi(OtBu)3) in a 3:2 ratio under inert conditions. The polynuclear bismuth oxido clusters, [Bi₅₀O₆₄(Ace)₂₂(H₂O)₁₀] 5 and [Bi₃₈O₄₅(CycH)₂₄(H₂O)₁₄] 10 were obtained using Bi2O3 under sonication in water and their composition confirmed through elemental and thermogravimetric analyses. The DMSO soluble complexes, 1, 2, 4, 5, 6, 7 and 9, were all assessed for their in-vitro activity against three strains of H. pylori (251, 26695 and B128). All compounds gave an MIC value of 6.25 μg/mL, indicating that bactericidal activity is insensitive to increased substitution by acetosulfamate or cyclamate at the Bi(III) centre.
Journal
Journal of Organometallic Chemistry
Publication Name
Journal of Organometallic Chemistry
Volume
724
ISBN/ISSN
1872-8561
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Pages Count
7
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Elsevier
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DOI
10.1016/j.jorganchem.2012.10.024