Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice

Journal Publication ResearchOnline@JCU
Kasahara, Maki;Groenink, Lucianne;Kas, Martien J.H.;Bijlsma, Elisabeth Y.;Olivier, Berend;Sarnyai, Zoltán
Zoltan Sarnyai
Abstract

We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction.

Journal

Behavioural Brain Research

Publication Name

N/A

Volume

218

ISBN/ISSN

0166-4328

Edition

N/A

Issue

2

Pages Count

6

Location

N/A

Publisher

Elsevier

Publisher Url

N/A

Publisher Location

N/A

Publish Date

N/A

Url

N/A

Date

N/A

EISSN

N/A

DOI

10.1016/j.bbr.2010.12.029