MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity

Perrigoue, Jacqueline G.;Saenz, Steven A.;Siracusa, Mark C.;Allenspach, Eric J.;Taylor, Betsy C.;Giacomin, Paul R.;Nair, Meera G.;Du, Yurong;Zaph, Colby;van Rooijen, Nico ;Comeau, Michael R.;Pearce, Edward J.;Laufer, Terri M.;Artis, David

Paul Giacomin

Abstract

Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II–dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.

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Nature Immunology

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1529-2916

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Nature Publishing Group

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DOI

10.1038/ni.1740