Identifying the cells breaching self-tolerance in autoimmunity

Journal Publication ResearchOnline@JCU
Benson, Robert A.;Patakas, Agapitos;Conigliaro, Paola;Rush, Catherine M.;Garside, Paul;McInnes, Iain B.;Brewer, James M.
Catherine Rush
Abstract

Activation of auto-reactive T cells by activated dendritic cells (DCs) presenting self-Ag is widely assumed to be the precipitating event in the development of autoimmune disease. However, despite such widely held preconceptions, supporting data are scarce and subjective, particularly in experimental arthropathy. We have adapted a novel murine model of breach of self-tolerance allowing evaluation of the contribution of endogenous DCs to the development of autoimmune responses and disease. For the first time, we reveal the critical role played by conventional DCs, and the timing and location of this process. We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity.

Journal

Journal of Immunology

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Volume

184

ISBN/ISSN

1550-6606

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Issue

11

Pages Count

8

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Publisher

American Association of Immunologists

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EISSN

N/A

DOI

10.4049/jimmunol.0903951