Optimization of a multi-epitope self-assembling and self-adjuvanting TB nanoparticle vaccine
Role
Co Investigator
Description
We have developed a self-assembling and self-adjuvanting peptide-based nanovaccine that significantly improves the immunity and efficacy of BCG in a mouse model of TB when used as a booster vaccine. This peptide-based nanovaccine platform has multiple benefits, is cold-chain and adjuvant independent and offers great translational potential. In this project we aim to further develop the vaccine by increasing its immunogenicity and protective efficacy through the incorporation of additional epitopes and host binding peptides. This study could improve future front-line management of TB in Far North Queensland and beyond, with the ultimate goal to benefit human health globally.
Date
01 Jun 2025 - 31 May 2026
Project Type
N/A
Keywords
tuberculosis;vaccine;nanoparticle;peptide
Funding Body
Far North Queensland Hospital Foundation
Amount
49972
Project Team
Guangzu Zhao;Andreas Kupz;Julia Seifert