Development of a preventive strategy for rheumatic heart disease using an experimental model (Old ID 19355)

National Health and Medical Research Council (NHMRC)
Catherine Rush
Role

Chief Investigator

Description

Based on animal studies, we aim to demonstrate that the worsening of heart damage seen in patients with rheumatic heart disease (RHD) is due to repeated infections with bacteria (group A streptococci: GAS). The heart damage is caused by continual immune damage to the heart and valves and this has adverse effects on heart function. We will also investigate a novel way to prevent the development of RHD.

Date

01 Jan 2012 - 31 Dec 2016

Project Type

N/A

Keywords

Rheumatic Diseases;Animal model;Immunopathology;Cardiovascular;Disease Prevention;Infectious diseases

Funding Body

National Health and Medical Research Council (NHMRC)

Amount

358712.5

Project Team

Lisa Chilton;Jacinta Elston;Davina Gorton;Catherine Rush