Seed funding -improving stroke management by characterising the ischaemic penumrba proteome.
Role
Chief Investigator
Description
Current therapies for stroke work by restoring the blood supply to the brain to rescue oxygen-starved tissue at risk of dying (known as the ischaemic penumbra). Consumer groups highlight that therapies to slow the death of cells in the penumbra is a priority, however, surprisingly little is known about the biology of this tissue. This study will utilise laboratory models of stroke, and apply modern imaging, proteomic and bioinformatic approaches to characterise the major pathways driving penumbra phenotype. Generated data will provide a world's first perspective into penumbra biology as an important foundation for subsequent grants seeking to test potential therapuetic targets.
Date
01 Jul 2024 - 30 Jun 2025
Project Type
INTERNAL_RESARCH_GRANT
Keywords
stroke;penumbra;proteomics
Funding Body
James Cook University
Amount
0
Project Team
Jonathan Golledge;Alex Trollope;Liza van Eijk