RNA Sequencing investigation of box jellyfish, Chironex fleckeri, venom effect on human cell models. (Old ID 27838)
Role
Chief Investigator
Description
Box jellyfish (Chironex fleckeri) envenomation results in severe pain, inflammation, cardiovascular distress and causes approximately one death per year. However, the mechanism of action the venom induces these effects on humans is poorly understood. Currently, treatment typically consists of basic first aid and analgesia. This research will use RNA-sequencing to discover how human cell lines respond to C. fleckeri venom and its constituents. We believe this approach may contribute to an improved understanding of the mechanistic pathways involved in the venom's pathology and novel envenomation treatment.
Date
03 Oct 2022 - 30 Sep 2023
Project Type
GRANT
Keywords
Chironex Fleckeri/Box Jellyfish;Human Neuronal response;Human immune response;RNA Sequencing;Genomics and Transcriptomics;Venom/Toxicology
Funding Body
Australian Lions Foundation
Amount
7000
Project Team
Ludwig Lopata