Novel therapeutics for diabetes sourced from Northern Australian biota. (Old ID 27321)
Role
Chief Investigator
Description
The aim of this project is to develop lead diabetes drug candidates from hookworm saliva and build a package for multinational commercial investment. The project aims to deliver the following outcomes: 1. Screen a synthetic hookworm library (consisting of hundreds of hookworm proteins) for anti-inflammatory activity and express lead candidates using pharmaceutical industry standard techniques. 2. Assess efficacy of leads in mouse models of diet-induced T2D. 3. Understand the mechanism of lead drug action and prioritize candidates for progression into clinical development. 4. Set the scene for a burgeoning biotech industry in Northern Australia that is differentiated from those in the south, and indeed globally, by capitalizing on the unique biodiversity of the region and the therapeutic opportunities it presents.
Date
01 Jul 2021 - 30 Jun 2022
Project Type
GRANT
Keywords
Diabetes;hookworm library;hookworm saliva
Funding Body
CRC for Developing Northern Australia, Macrobiome Therapeutics
Amount
300000
Project Team
Kim Miles;Yide Wong;Paul Giacomin;Darren Pickering;Mel Timms;Roland Ruscher