Suspected Pulmonary Embolism Exclusion with D-dimers in Emergency Departments (SPEED-ED)
Role
Principal Investigator
Description
Pulmonary embolism (PE) is defined as obstruction of the pulmonary artery or one of its branches, most often by blood clot circulating from a distant site. Acute PE is common, potentially fatal and is associated with a major global burden of disease. predicted to increase in an ageing society Global hospital admission rates have also increased in recent years. The clinical presentation of PE is non-specific due to an overlap of clinical features with other conditions and can vary from asymptomatic to sudden death, meaning the diagnosis is both challenging to make, and important. This has resulted in the development of clinical decision rules (CDRs) and algorithms to aid the diagnostic process and minimise practice variation. These rules employ a combination of clinical probability assessment, laboratory plasma D-dimer measurement and imaging modalities like Computed Tomography Pulmonary Angiography (CTPA) or Ventilation-Perfusion(V/Q) scan. Modified Wells’ score, Revised Geneva Score, Pulmonary Embolism Rule out Criteria (PERC) and Age-adjusted D-dimer threshold are the major validated CDRs in current clinical use that aim to improve consistency and minimise variation.
Date
16 Jul 2024 - 01 Dec 2026
Project Type
GRANT
Keywords
Pulmonary embolism;global burden of disease;clinical decision rules
Funding Body
Emergency Medicine Foundation
Amount
0
Project Team
N/A