Unravelling novel immune parameters that correlate with BCG vaccination in humans. (Old ID 27409)
Role
Principal Investigator
Description
Tuberculosis (TB) is a leading infectious cause of death globally and is over-represented in Indigenous people in Far North Queensland. The only licensed TB vaccine, Bacille Calmette– Guérin (BCG), which is universally used to prevent TB in children, fails to protect against pulmonary TB in adults, and it is not known why protection wanes in adolescence. This project aims to unravel the immunological correlates that correlate with BCG-mediated protection in humans. Using high-dimensional immune profiling and microbiome analyses we will compare immune responses to BCG vaccination with Mycobacterium tuberculosis infection in children in the FNQ/Torres Strait region.
Date
02 Nov 2021 - 02 Nov 2022
Project Type
GRANT
Keywords
Mycobacterium Tuberculosis;Mycobacteria;Vaccine Development;Immunology;Infectious disease;BCG;Bacille Calmette– Guérin
Funding Body
Tropical Australian Academic Health Centre Limited
Amount
20000
Project Team
N/A