Isolation and pre-clinical evaluation of small molecule anti-inflammatory compounds from hookworms (Old ID 21589)
Role
Principal Investigator
Description
Taking cues from millennia of host-parasite co evolution, my research envisions harnessing the unique ability of hookworm to modulate inflammation and would determine the therapeutic potential of the low molecular weight cultured excretory/secretory (<10 kDa) and the somatic extracts of adult hookworms. It aims on: (1) Isolating, structure elucidating and identifying small drug lead compounds; (2) Derivatizing these bioactive molecules; and (3) Evaluating the anti-inflammatory activity of rude extracts and their compounds using in vivo and ex vivo experimental mouse models. This study would lead to novel anti-inflammatory drug discovery that has implications to the Australian patients with inflammatory bowel diseases.
Date
01 Jan 2015 - 30 Jun 2019
Project Type
FELLOWSHIP
Keywords
Anti-inflammatory;Drug Discovery;Hookworm;Excretory/secretory Proteins;Inflammatory Bowel Disease;small molecule
Funding Body
National Health and Medical Research Council (NHMRC)
Amount
309436
Project Team
N/A