Development of a T cell based vaccine against malaria from proteome-wide T cell screening (Old ID 27815)

National Institute of Health
Denise Doolan
Role

Principal Investigator

Description

This proposal is targeting the development of a malaria vaccine that induced robust and protective T cell responses against the liver stage of the Plasmodium parasite. From the complete P. falciparum pre-erythrocytic (sporozoite/liver) stage proteome, we will identify, characterize, and credential priority antigens discovered by proteome-based T cell screening; and will progress protective antigens through preclinical development to provide a vaccine candidate capable of inducing robust and sustained protective immunity against malaria.

Date

01 Apr 2022 - 31 Mar 2027

Project Type

GRANT

Keywords

Malaria Vaccines;T cell;Antigen Discovery;Preclinical development

Funding Body

National Institute of Health

Amount

2445413

Project Team

Carla Proietti;David Pattinson