Preclinical evaluation of novel drug lead compounds discovered from Wet Tropics plant (Old ID 28949)
Role
Principal Investigator
Description
Inflammatory bowel disease (IBD) affects 1 in 250 Australians including the people living in Far North Queensland (FNQ). There is no cure for this debilitating disease. Inspired by the Wet Tropics, we have isolated two compounds that demonstrated strong in vitro anti-inflammatory activity. A provisional patent has been approved for these two compounds. To further develop them into the marketable drug lead candidates, this proposed project will endeavor to achieve preclinical evaluation of these two novel compounds using the two commonly used animal models of IBD- Trinitrobenzenesulfonic acid (TNBS) and T cell transfer models of colitis.
Date
01 Jan 2023 - 15 Mar 2025
Project Type
GRANT
Keywords
Wet Tropics;Biodiscovery;Inflammatory Bowel Disease;Anti-inflammatory drug lead;Natural products;Drug leads
Funding Body
Far North Queensland Hospital Foundation
Amount
50000
Project Team
Karma Yeshi;Paul Giacomin