Novel therapeutics for diabetes sourced from Northern Australian biota. (Old ID 27346)
Role
Principal Investigator
Description
he aim of this project is to develop lead diabetes drug candidates from hookworm saliva and build a package for multinational commercial investment. The project aims to deliver the following outcomes: 1. Screen a synthetic hookworm library (consisting of hundreds of hookworm proteins) for anti-inflammatory activity and express lead candidates using pharmaceutical industry standard techniques. 2. Assess efficacy of leads in mouse models of diet-induced T2D. 3. Understand the mechanism of lead drug action and prioritize candidates for progression into clinical development. 4. Set the scene for a burgeoning biotech industry in Northern Australia that is differentiated from those in the south, and indeed globally, by capitalizing on the unique biodiversity of the region and the therapeutic opportunities it presents.
Date
02 Aug 2021 - 30 Jun 2023
Project Type
GRANT
Keywords
Diabetes;Hookworm Library;Hookworm saliva
Funding Body
CRC for Developing Northern Australia
Amount
1192109
Project Team
Alex Loukas