Role
Principal Investigator
Description
In this project, we investigate regulatory processes in cancer, whereby the control of protein generation from DNA genetic code is disrupted. This process is referred to as intron retention (IR), a phenomenon, which allows “junk” DNA to enter the cell. IR plays a critical role in cancer development, yet the mechanism of its involvement remains unresolved. We hypothesise that IR can significantly interfere with other forms of gene regulation via ‘cross-talk’. This introduces a distortion of gene regulation, which is amenable to therapeutic manipulation. Our enhanced understanding of gene-regulatory cross-talk will facilitate improved IR-directed therapies.
Date
01 Jan 2020 - 30 Jun 2024
Project Type
GRANT
Keywords
Bioinformatics;Breast Cancer;Gene Regulation;Computational Biology;Leukaemia;RNA biology
Funding Body
Cancer Council NSW
Amount
404943
Project Team
N/A