Deciphering cancer gene regulation (Old ID 27432)

Cancer Council NSW
Role

Principal Investigator

Description

In this project, we investigate regulatory processes in cancer, whereby the control of protein generation from DNA genetic code is disrupted. This process is referred to as intron retention (IR), a phenomenon, which allows “junk” DNA to enter the cell. IR plays a critical role in cancer development, yet the mechanism of its involvement remains unresolved. We hypothesise that IR can significantly interfere with other forms of gene regulation via ‘cross-talk’. This introduces a distortion of gene regulation, which is amenable to therapeutic manipulation. Our enhanced understanding of gene-regulatory cross-talk will facilitate improved IR-directed therapies.

Date

01 Jan 2020 - 30 Jun 2024

Project Type

GRANT

Keywords

Bioinformatics;Breast Cancer;Gene Regulation;Computational Biology;Leukaemia;RNA biology

Funding Body

Cancer Council NSW

Amount

404943

Project Team

N/A