Targeting Inflammasome Activation To Combat Infections With Intracellular Pathogens (Old ID 20303)
Role
Principal Investigator
Description
The project will investigate the potential to specifically target intracellular sensors, so called inflammasomes, to enhance immunity against the intracellular pathogens Mycobacterium tuberculosis and Toxoplasma gondii. Particular emphasis will be placed on the regulation of inflammasome-mediated secretion of iterleukin-18 and subsequent initiation of protective interferon-gamma production. The project aims to identify novel host-pathogen interactions that can enhance effective control and clearance of these pathogens and to test the associated molecules in murine infection models as well as primary human samples. Results obtained from this research project may aid in the development of novel vaccine candidates and immunomodulatory strategies against intracellular pathogens.
Date
01 Jun 2013 - 31 Dec 2017
Project Type
FELLOWSHIP
Keywords
Mycobacterium tuberculosis;Toxoplasma gondii (Apicomplexa);Innate immunity;Vacine development;Immunology;Infectious Disease
Funding Body
National Health and Medical Research Council (NHMRC)
Amount
325084
Project Team
Nicholas Smith