Research & Innovation Services

Paul Giacomin

Paul Giacomin

Arnold Mangott

Arnold Mangott

Personal Protective Biosystems - Membranes and commensal helminths (MaCH) (Old ID 26776)
Paul Giacomin
15 Apr 2021 - 14 Apr 2026
The proposed work will design a 2-part protective biosystem capable of dramatically reducing the burden of personal protective equipmetn (PPE). The first component consists of a garmetn system with a dynamic, selectively permeable graphene composite barrier laqyer and integrated self-cleaning functionality provided by metal oranic frameworks. The sedon component (including work to be done at JCU) leverages genetic modification of human helminth parasites (hookworms and/or schistosomes) to provide prophylaxis and neutralisation of various chemical and/or biological agents.
Novel biologics for pediatric inflammatory bowel disease and necrotising enterocolitis, inspired by host-parasite co-evolution. (Old ID 27128)
Paul Giacomin
01 Feb 2021 - 31 Aug 2022
Inflammatory bowel diseases (IBD) pose a major health burden with severe symptoms, and IBD onset in childhood is on the rise. Necrotising enterocolitis (NEC) is another inflammatory bowel condition that affects preterm infants, and in which inflamed parts of the gut die. Current treatment methods are insufficient. Intestinal parasites have developed strategies to modulate our immune responses through secreted proteins. We identified seven helminth-secreted proteins that suppress gut inflammation. We now would like to assess which of our preselected proteins are best in the context of early life IBD and NEC.

Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior

Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites

A C-terminal fragment of chlorotoxin retains bioactivity and inhibits cell migration

Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lung

The future of aquatic protein: implications for protein sources in aquaculture diets

  • 2019
  • Elsevier
  • Researchers:Kelly CondonDean JerryArnold MangottJan Strugnell

Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial

Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps

Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities

IL-17A moonlighting in lung type 2 immunity

Title: Advance QLD Mid-Career Fellow, James Cook Univers
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2016
End Date: 01 Jan 2019
Title: NHMRC CJ Martin Research Fellow, James Cook University, Cairns
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2012
End Date: 01 Jan 2015
Title: NHMRC CJ Martin Research Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2010
End Date: 01 Jan 2012
Title: Research Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2009
End Date: 01 Jan 2009
Title: Sir Keith Murdoch Fellow, University of Pennsylvania
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2008
End Date: 01 Jan 2009
Title: PhD candidate, University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2003
End Date: 01 Jan 2008
Title: BSc (Hons), University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 2002
End Date: 01 Jan 2002
Title: BSc (Biomedical Science), University of Adelaide
Reseracher: Paul Giacomin (Research Development and Partnership Advisor)
Start Date: 01 Jan 1999
End Date: 01 Jan 2002