photo

Thaddeus Wu

Projects

1

Publications

4

Awards

0

Biography

Dr Wu joined James Cook University in July 2022 as an Early Career Postdoctoral Researcher in A/Prof. Ulf Schmitz's team. Additionally, he holds the position of Lecturer in Mathematical and Computational Biology in the Department of Molecular & Cell Biology (CPHMVS).

Thaddeus earned his PhD in Applied Mathematics from Monash University in March 2022. He conducts research in mathematical and computational biology, utilising his experience in mathematical modelling, algorithm development, and statistical analysis to study the mechanisms of cell fate determination.

Currently, Thaddeus is focused on developing a novel mathematical framework to describe how mechanisms of alternative splicing and isoform expression at the single-cell level regulate cell fate determination.

Available HDR Student Projects

Research

Research Interests

Mathematical Modelling

Mathematical and Computational Biology

Systems Biology

Stochastic Modelling

Dynamical Systems

Projects
Innovative Therapeutic Strategies Targeting Aberrant Gene Regulation in Aggressive Breast Cancer
01 Jul 2024 - 30 Jun 2025

Teaching

Research Advisor Accreditation
Advisor Type

Secondary

Taught Modules
[BC5203] Advanced BioinformaticsLecturer
2024
[BC3203] BioinformaticsTutor
2022
[BC5203] Advanced BioinformaticsLecturer
2023
[BC3203] BioinformaticsLecturer
2024
[BM1000] Introductory Biochemistry and MicrobiologyTutor
2022
[BC3203] BioinformaticsTutor
2023
[TV1102] Cell Biology and Biochemistry for Veterinary Science and AgricultureTutor
2022
[BC5203] Advanced BioinformaticsTutor
2022
Current JCU Research Students
Neural network based model for cell type-specific isoform expression pattern
Master of Philosophy (Medical, Molecular and Veterinary Sciences)

Activities

Associations
Centre for Tropical Bioinformatics and Molecular Biology
2022
Australian Mathematical Society
2022
Languages
Mandarin
Chinese
English
Employment
Postdoctoral Researcher and Lecturer, James Cook University
2022

Output

Single-cell and long-read sequencing to enhance modelling of splicing and cell-fate determination
2023
Wu, Siyuan; Schmitz, Ulf (2023) 'Single-cell and long-read sequencing to enhance modelling of splici. Computational and Structural Biotechnology Journal, 21 :2373-2380. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
A robust method for designing multistable systems by embedding bistable subsystems
2022
Wu, Siyuan; Zhou, Tianshou; Tian, Tianhai (2022) 'A robust method for designing multistable systems . npj Systems Biology and Applications, 8 (10). [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
A non-linear reverse-engineering method for inferring genetic regulatory networks
2020
Wu, Siyuan; Cui, Tiangang; Zhang, Xinan; Tian, Tianhai (2020) 'A non-linear reverse-engineering meth. PeerJ, 8 . [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Mathematical Modelling of Genetic Network for Regulating the Fate Determination of Hematopoietic Stem Cells
2019
Wu, Siyuan; Cui, Tiangang; Tian, Tianhai (2019) 2018 IEEE International Conference on Bioinformatics...
Conference Publication Open Access ResearchOnline@JCU